ENYEDY, Istvan J.: search on Z-Library

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1

Can we use docking and scoring for hit-to-lead optimization?

Istvan J. Enyedy, William J. Egan

Journal:

Journal of Computer-Aided Molecular Design

Year:

2008

Language:

english

File:

PDF, 553 KB

english, 2008

2

Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity

May-Dracka, Tricia L., Arduini, Robert, Bertolotti-Ciarlet, Andrea, Bhisetti, Govinda, Brickelmaier, Margot, Cahir-McFarland, Ellen, Enyedy, Istvan, Fontenot, Jason D., Hesson, Thomas, Little, Kevin,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 1.44 MB

english, 2018

3

Discovery of Small-Molecule Inhibitors of Bcl-2 through Structure-Based Computer Screening

Enyedy, Istvan J., Ling, Yan, Nacro, Kassoum, Tomita, York, Wu, Xihan, Cao, Yeyu, Guo, Ribo, Li, Bihua, Zhu, Xiaofeng, Huang, Ying, Long, Ya-Qiu, Roller, Peter P., Yang, Dajun, Wang, Shaomeng

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 462 KB

english, 2001

4

Identification of Potent and Selective Amidobipyridyl Inhibitors of Protein Kinase D

Meredith, Erik L., Beattie, Kimberly, Burgis, Robin, Capparelli, Michael, Chapo, Joseph, DiPietro, Lucian, Gamber, Gabriel, Enyedy, Istvan, Hood, David B., Hosagrahara, Vinayak, Jewell, Charles, Koch,

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.40 MB

english, 2010

5

In silico prediction of hERG inhibition

Jing, Yankang, Easter, Alison, Peters, David, Kim, Norman, Enyedy, Istvan J

Journal:

Future Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 961 KB

english, 2015

6

Design, synthesis and identification of novel, orally bioavailable non-covalent Nrf2 activators

Ma, Bin, Lucas, Brian, Capacci, Andrew, Yin-Shiang Lin, Edward, Howard Jones, John, Dechantsreiter, Michael, Enyedy, Istvan, Marcotte, Douglas, Xiao, Guangqing, Li, Bing, Richter, Karl

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2019

File:

PDF, 1.68 MB

2019

7

Human PLD structures enable drug design and characterization of isoenzyme selectivity

Metrick, Claire M., Peterson, Emily A., Santoro, Joseph C., Enyedy, Istvan J., Murugan, Paramasivam, Chen, TeYu, Michelsen, Klaus, Cullivan, Michael, Spilker, Kerri A., Kumar, P. Rajesh, May-Dracka, T

Journal:

Nature Chemical Biology

Year:

2020

File:

PDF, 4.85 MB

2020

8

ChemInform Abstract: Synthesis and Biological Evaluation of 1-Azabicyclo[3.2.1]octanes: New Dopamine Transporter Inhibitors.

Amir P. Tamiz, Miles P. Smith, Istvan Enyedy, Judith Flippen-Anderson, Mei Zhang, Kenneth M. Johnson, Alan P. Kozikowski

Journal:

Year:

2000

File:

PDF, 30 KB

2000

9

Complexation of desferricoprogen with trivalent Fe, Al, Ga, In and divalent Fe, Ni, Cu, Zn metal ions: effects of the linking chain structure on the metal binding ability of hydroxamate based siderophores

Éva A. Enyedy, István Pócsi, Etelka Farkas

Journal:

Journal of Inorganic Biochemistry

Year:

2004

Language:

english

File:

PDF, 418 KB

english, 2004

10

2,3-Disubstituted quinuclidines as a novel class of dopamine transporter inhibitors

Sukumar Sakamuri, Istvan J Enyedy, Wahiduz A Zaman, Srihari R Tella, Alan P Kozikowski, Judith L Flippen-Anderson, Tivadar Farkas, Kenneth M Johnson, Shaomeng Wang

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 481 KB

english, 2003

11

Interactions in Tetravalent and Pentavalent Phosphonate Esters of Ser at the Active Site of Serine Enzymes

Enyedy, Istvan, Bencsura, Akos, Kovach, Ildiko

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Year:

1996

Language:

english

File:

PDF, 256 KB

english, 1996

12

Discovery of a Novel Dopamine Transporter Inhibitor, 4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-Methylphenyl Ketone, as a Potential Cocaine Antagonist through 3D-Database Pharmacophore Searching. Molecular Modeling, Structure−Activity Relationships, and Behavioral Pharmacological Studies

Wang, Shaomeng, Sakamuri, Sukumar, Enyedy, Istvan J., Kozikowski, Alan P., Deschaux, Olivier, Bandyopadhyay, Bidhan C., Tella, Srihari R., Zaman, Wahiduz A., Johnson, Kenneth M.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 229 KB

english, 2000

13

Inhibitors of protein–protein interactions: New methodologies to tackle this challenge

Silvian, Laura, Enyedy, Istvan, Kumaravel, Gnanasambandam

Journal:

Drug Discovery Today: Technologies

Year:

2013

Language:

english

File:

PDF, 465 KB

english, 2013

14

3,5-Diarylazoles as novel and selective inhibitors of protein kinase D

Gabriel G. Gamber, Erik Meredith, Qingming Zhu, Wanlin Yan, Chang Rao, Michael Capparelli, Robin Burgis, Istvan Enyedy, Ji-Hu Zhang, Nicolas Soldermann, Kimberley Beattie, Olga Rozhitskaya, Keith A. K

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 2.18 MB

english, 2011

15

The statistics of virtual screening and lead optimization

McGann, Mark, Nicholls, Anthony, Enyedy, Istvan

Journal:

Journal of Computer-Aided Molecular Design

Year:

2015

Language:

english

File:

PDF, 1.23 MB

english, 2015

16

Probing the Active Site of Acetylcholinesterase by Molecular Dynamics of Its Phosphonate Ester Adducts †

Bencsura, Akos, Enyedy, Istvan Y., Kovach, Ildiko M.

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 634 KB

english, 1996

17

A self-consistent mechanism for dealkylation in soman-inhibited acetylcholinesterase

KOVACH, Ildiko M., AKHMETSHIN, Rinat, ENYEDY, Istvan J., VIRAGH, Carol

Journal:

Biochemical Journal

Year:

1997

Language:

english

File:

PDF, 457 KB

english, 1997

18

Molecular dynamics study of active-site interactions with tetracoordinate transients in acetylcholinesterase and its mutants

ENYEDY, Istvan J., KOVACH, Ildiko M., BENCSURA, Akos

Journal:

Biochemical Journal

Year:

2001

Language:

english

File:

PDF, 207 KB

english, 2001

19

ChemInform Abstract: Synthesis of 2-Alkyl-3-aryl-substituted Quinuclidines as Novel Dopamine Transporter Inhibitors.

Sukumar Sakamuri, Istvan J. Enyedy, Alan P. Kozikowski, Shaomeng Wang

Journal:

Year:

2001

File:

PDF, 30 KB

2001

20

Discovery of substituted 3,4-Diphenyl-thiazoles as a novel class of monoamine transporter inhibitors through 3-D pharmacophore search using a new pharmacophore model derived from mazindol

Istvan J Enyedy, Jiansuo Wang, Wahiduz A Zaman, Kenneth M Johnson, Shaomeng Wang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 160 KB

english, 2002

21

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

Marcotte, Douglas, Zeng, Weike, Hus, Jean-Christophe, McKenzie, Andres, Hession, Cathy, Jin, Ping, Bergeron, Chris, Lugovskoy, Alexey, Enyedy, Istvan, Cuervo, Hernan, Wang, Deping, Atmanene, Cédric, R

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.61 MB

english, 2013

22

Structural Basis of RasGRP Binding to High-Affinity PKC Ligands

Rong, Suo-Bao, Enyedy, Istvan J., Qiao, Lixin, Zhao, Lianyun, Ma, Dawei, Pearce, Larry L., Lorenzo, Patricia S., Stone, James C., Blumberg, Peter M., Wang, Shaomeng, Kozikowski, Alan P.

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 299 KB

english, 2002

23

Discovery of biaryl carboxylamides as potent RORγ inverse agonists

Chao, Jianhua, Enyedy, Istvan, Van Vloten, Kurt, Marcotte, Douglas, Guertin, Kevin, Hutchings, Richard, Powell, Noel, Jones, Howard, Bohnert, Tonika, Peng, Chi-Chi, Silvian, Laura, Hong, Victor Sukbon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.52 MB

english, 2015

24

Discovery of novel pyrazole-containing benzamides as potent RORγ inverse agonists

Wang, Tao, Banerjee, Daliya, Bohnert, Tonika, Chao, Jianhua, Enyedy, Istvan, Fontenot, Jason, Guertin, Kevin, Jones, Howard, Lin, Edward Y., Marcotte, Douglas, Talreja, Tina, Van Vloten, Kurt

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 3.70 MB

english, 2015

25

Iridals Are a Novel Class of Ligands for Phorbol Ester Receptors with Modest Selectivity for the RasGRP Receptor Subfamily †

Shao, Lei, Lewin, Nancy E., Lorenzo, Patricia S., Hu, Zengjian, Enyedy, Istvan J., Garfield, Susan H., Stone, James C., Marner, Franz-Josef, Blumberg, Peter M., Wang, Shaomeng

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 362 KB

english, 2001

26

Optimized angiotensin-converting enzyme activity assay for the accurate diagnosis of sarcoidosis

Csongrádi, Alexandra, Enyedi, Attila, Takács, István, Végh, Tamás, Mányiné, Ivetta S., Pólik, Zsófia, Altorjay, István Tibor, Balla, József, Balla, György, Édes, István, Kappelmayer, János, Tóth, Atti

Journal:

Clinical Chemistry and Laboratory Medicine

Year:

2018

Language:

english

File:

PDF, 1.17 MB

english, 2018

27

ChemInform Abstract: Pharmacophore-Based Discovery, Synthesis, and Biological Evaluation of 4-Phenyl-1-arylalkyl Piperidines as Dopamine Transporter Inhibitors.

Sukumar Sakamuri, Istvan J. Enyedy, Alan P. Kozikowski, Wahiduz A. Zaman, Kenneth M. Johnson, Shaomeng Wang

Journal:

Year:

2001

File:

PDF, 29 KB

2001

28

ChemInform Abstract: Pharmacophore-Based Discovery of 3,4-Disubstituted Pyrrolidines as a Novel Class of Monoamine Transporter Inhibitors.

Istvan J. Enyedy, Wahiduz A. Zaman, Sukumar Sakamuri, Alan P. Kozikowski, Kenneth M. Johnson, Shaomeng Wang

Journal:

Year:

2001

File:

PDF, 28 KB

2001

29

Synthesis of 2-alkyl-3-aryl-substituted quinuclidines as novel dopamine transporter inhibitors

Sukumar Sakamuri‡, Istvan J Enyedy†, §, ∣∣, Alan P Kozikowski†, ‡, Shaomeng Wang†, §, ∣∣

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 148 KB

english, 2000

30

Pharmacophore-Based discovery, synthesis, and biological evaluation of 4-phenyl-1-arylalkyl piperidines as dopamine transporter inhibitors

Sukumar Sakamuri, Istvan J Enyedy, Alan P Kozikowski, Wahiduz A Zaman, Kenneth M Johnson, Shaomeng Wang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 411 KB

english, 2001

31

Über den Venendruck und dessen Tagesschwankungen

Vitéz István v. Gönczy, Josef Kiss, Zoltán Enyedy

Journal:

Research in Experimental Medicine

Year:

1930

Language:

german

File:

PDF, 887 KB

german, 1930

32

Clinical experience with a new endobrochial blocker: the EZ-blocker

Végh, Tamás, Juhász, Marianna, Enyedi, Attila, Takács, István, Kollár, József, Fülesdi, Béla

Journal:

Journal of Anesthesia

Year:

2012

Language:

english

File:

PDF, 248 KB

english, 2012

33

Structural Basis of Binding of High-Affinity Ligands to Protein Kinase C: Prediction of the Binding Modes through a New Molecular Dynamics Method and Evaluation by Site-Directed Mutagenesis

Pak, Youngshang, Enyedy, Istvan J., Varady, Judith, Kung, Justin W., Lorenzo, Patricia S., Blumberg, Peter M., Wang, Shaomeng

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 419 KB

english, 2001

34

Identification and experimental confirmation of novel cGMP efflux inhibitors by virtual ligand screening of vardenafil-analogues

Kashgari, Farzane Kuresh, Ravna, Aina, Sager, Georg, LysÃ¥, Roy, Enyedy, Istvan, Dietrichs, Erik Sveberg

Journal:

Biomedicine & Pharmacotherapy

Year:

2020

File:

PDF, 1.12 MB

2020

35

Molecular Modeling, Structure–Activity Relationships and Functional Antagonism Studies of 4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-Methylphenyl Ketones as a Novel Class of Dopamine Transporter Inhibitors

Shaomeng Wang, Sukumar Sakamuri, Istvan J. Enyedy, Alan P. Kozikowski, Wahiduz A. Zaman, Kenneth M. Johnson

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 287 KB

english, 2001

36

Identification of Orally Available Naphthyridine Protein Kinase D Inhibitors

Meredith, Erik L., Ardayfio, Ophelia, Beattie, Kimberly, Dobler, Markus R., Enyedy, Istvan, Gaul, Christoph, Hosagrahara, Vinayak, Jewell, Charles, Koch, Keith, Lee, Wendy, Lehmann, HansJoerg, McKinse

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 3.83 MB

english, 2010

37

Antisense and small-molecule modulation of diacylglycerol acyltransferase

Hubbard, Brian K, Enyedy, Istvan, Gilmore, Thomas A, Serrano-Wu, Michael H

Journal:

Expert Opinion on Therapeutic Patents

Year:

2007

Language:

english

File:

PDF, 319 KB

english, 2007

38

Discovery of Substituted 3,4-Diphenyl-thiazoles as a Novel Class of Monoamine Transporter Inhibitors Through 3-D Pharmacophore Search Using a New Pharmacophore Model Derived from Mazindol.

Istvan J. Enyedy, Jiansuo Wang, Wahiduz A. Zaman, Kenneth M. Johnson, Shaomeng Wang

Journal:

Year:

2002

Language:

english

File:

PDF, 30 KB

english, 2002

39

Virtual Screening for Kinase Targets

Muegge, Ingo, Enyedy, Istvan J.

Journal:

Current Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 324 KB

english, 2004

40

Discovery of biaryls as RORγ inverse agonists by using structure-based design

Enyedy, Istvan J., Powell, Noel A., Caravella, Justin, Vloten, Kurt van, Chao, Jianhua, Banerjee, Daliya, Marcotte, Douglas, Silvian, Laura, McKenzie, Andres, Hong, Victor Sukbong, Fontenot, Jason D.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 638 KB

english, 2016

41

Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: new dopamine transporter inhibitors

Amir P Tamiz, Miles P Smith, Istvan Enyedy, Judith Flippen-Anderson, Mei Zhang, Kenneth M Johnson, Alan P Kozikowski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 238 KB

english, 2000

42

Origins and Diversity of the Aging Reaction in Phosphonate Adducts of Serine Hydrolase Enzymes: What Characteristics of the Active Site do They Probe?

Bencsura, Akos, Enyedy, Istvan, Kovach, Ildiko M.

Journal:

Year:

1995

Language:

english

File:

PDF, 3.29 MB

english, 1995

43

Molecular Modeling Studies of the Akt PH Domain and Its Interaction with Phosphoinositides

Rong, Suo-Bao, Hu, Youhong, Enyedy, Istvan, Powis, Garth, Meuillet, Emmanuelle J., Wu, Xiongwu, Wang, Renxiao, Wang, Shaomeng, Kozikowski, Alan P.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 588 KB

english, 2001

44

Effects of side chain amino nitrogen donor atoms on metal complexation of aminohydroxamic acids: New diaminohydroxamates chelating Ni(ii) more strongly than Fe(iii)

Enyedy, Éva A., Csóka, Hajnalka, Lázár, István, Micera, Giovanni, Garribba, Eugenio, Farkas, Etelka

Journal:

Journal of the Chemical Society Dalton Transactions

Year:

2002

Language:

english

File:

PDF, 228 KB

english, 2002

45

Substituted aminobenzimidazole pyrimidines as cyclin-dependent kinase inhibitors

Sharad Verma, Dhanapalan Nagarathnam, Jianxing Shao, Lei Zhang, Jin Zhao, Yamin Wang, Tindy Li, Eric Mull, Istvan Enyedy, Chunguang Wang, Qingming Zhu, Martha Altieri, Jerold Jordan, Thu-Thi-Anh Dang,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 246 KB

english, 2005

46

Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors

Istvan J Enyedy, Wahiduz A Zaman, Sukumar Sakamuri, Alan P Kozikowski, Kenneth M Johnson, Shaomeng Wang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 527 KB

english, 2001

47

Alternate Pathways for Acetic Acid and Acetate ion Release from Acetylcholinesterase: a Molecular Dynamics Study

Enyedy, Istvan J., Kovach, Ildiko M., Brooks, Bernard R.

Journal:

Journal of the American Chemical Society

Year:

1998

Language:

english

File:

PDF, 190 KB

english, 1998

48

In vivo imaging of Aminopeptidase N (CD13) receptors in experimental renal tumors using the novel radiotracer 68Ga-NOTA-c(NGR)

Máté, Gábor, Kertész, István, Enyedi, Kata Nóra, Mező, Gábor, Angyal, János, Vasas, Nikolett, Kis, Adrienn, Szabó, Éva, Emri, Miklós, Bíró, Tamás, Galuska, László, Trencsényi, György

Journal:

European Journal of Pharmaceutical Sciences

Year:

2015

Language:

english

File:

PDF, 2.29 MB

english, 2015

49

Structure-Based Approach for the Discovery of Bis-benzamidines as Novel Inhibitors of Matriptase

Enyedy, Istvan J., Lee, Sheau-Ling, Kuo, Angera H., Dickson, Robert B., Lin, Chen-Yong, Wang, Shaomeng

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 564 KB

english, 2001

50

Combined application of angiotensin converting enzyme and chitotriosidase analysis improves the laboratory diagnosis of sarcoidosis

Enyedi, Attila, Csongrádi, Alexandra, Altorjay, István T., Beke, Gergő L., Váradi, Csongor, Enyedi, Enikő E., Kiss, Dorina R., Bányai, Emese, Kalina, Edit, Kappelmayer, János, Tóth, Attila, Papp, Zolt

Journal:

Clinica Chimica Acta

Year:

2019

Language:

english

File:

PDF, 1.09 MB

english, 2019

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